Article

Brain atrophy progression in Parkinson’s disease is shaped by connectivity and local vulnerability

2021-06-09

Abstract excerpt

Atrophy in multiple brain regions has been reported in the early stages of Parkinson’s Disease, but there have been few longitudinal studies. How intrinsic properties of the brain, such as anatomical connectivity, local cell type distribution and gene expression combine to determine the pattern of disease progression remains unknown. One hypothesis proposes that the disease stems from prion-like propagation of mis...

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Literature Corpus work: c7cab162-22e9-521c-b974-47c6b8fbf357
DOI: 10.1101/2021.06.08.21258321

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