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Article

Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns

13 Dec 2021

Abstract excerpt

Parkinson's disease is a progressive neurodegenerative disorder characterized by the intracellular accumulation of insoluble alpha-synuclein aggregates into Lewy bodies and neurites. Increasing evidence indicates that Parkinson's disease progression results from the spread of pathologic alpha-synuclein through neuronal networks. However, the exact mechanisms underlying the propagation of abnormal proteins in the...

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PMID: 34910119
DOI: 10.1093/brain/awab440

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