Article

Predicting longitudinal brain atrophy in Parkinson’s disease using a Susceptible-Infected-Removed agent-based model

2022-05-01

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by accumulation of abnormal isoforms of alpha-synuclein. Alpha-synuclein is proposed to act as a prion in PD: in its misfolded pathologic state it favours the misfolding of normal alpha-synuclein molecules, spreads trans-neuronally, and causes neuronal or synaptic damage as it accumulates. This theory remains contr...

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Literature Corpus work: adab5875-66b5-5711-b350-dbf79fa910d8
DOI: 10.1101/2022.05.01.22274521

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