Article

Network connectivity and local transcriptomic vulnerability underpin cortical atrophy progression in Parkinson's disease

2023-04-26

Abstract excerpt

Parkinson's disease pathology is hypothesized to spread through the brain via axonal connections between regions and further modulated by local vulnerabilities within those regions. The resulting changes to brain morphology have previously been demonstrated in both prodromal and de novo Parkinson's disease patients. However, it remains unclear whether the pattern of atrophy progression in Parkinson's disease over...

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Literature Corpus work: f74ef581-5586-513e-9eb0-e1efd22eed28
DOI: 10.1101/2023.04.20.23288538

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