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Article

Regional transcriptional architecture of Parkinson’s disease pathogenesis and network spread

4 Jul 2019

Abstract excerpt

Although a significant genetic contribution to the risk of developing sporadic Parkinson's disease has been well described, the relationship between local genetic factors, pathogenesis, and subsequent spread of pathology throughout the brain has been largely unexplained in humans. To address this question, we use network diffusion modelling to infer probable pathology seed regions and patterns of disease spread...

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Share to Advanced Neuroimaging Techniques and Applications
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PMID: 31359041
DOI: 10.1093/brain/awz223

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