Article

Long-read sequencing technology indicates genome-wide effects of non-B DNA on polymerization speed and error rate

2017-12-21

Abstract excerpt

<h4>ABSTRACT</h4> DNA conformation may deviate from the classical B-form in ~13% of the human genome. Non-B DNA regulates many cellular processes; however, its effects on DNA polymerization speed and accuracy have not been investigated genome-wide. Such an inquiry is critical for understanding neurological diseases and cancer genome instability. Here we present the first simultaneous examination of DNA polymeriza...

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Literature Corpus work: 46097f15-0c92-5c6b-9b41-a378e622ed10
DOI: 10.1101/237461

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