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Z-DNA-induced genomic instability in the human pangenome

2026-07-20

Abstract excerpt

<title>Abstract</title> <p> Z-DNA is a non-canonical, left-handed nucleic acid conformation with roles in gene regulation, genomic variation, and genome instability. Recent advances in long-read sequencing enable systematic interrogation of Z-DNA in repetitive and previously unresolved parts of the human genome. Leveraging the complete telomere-to-telomere reference human genome and 464 haplotype-resolved genome...

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Literature Corpus work
d6e15ed1-98ee-57b4-9b32-7e6acb7930ba
DOI
10.21203/rs.3.rs-10129918/v1
Open publication

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