Article

DNA polymerase stalling at structured DNA constrains the expansion of Short Tandem Repeats

2020-06-20

Abstract excerpt

<h4>Background</h4> Short tandem repeats (STRs) contribute significantly to de novo mutagenesis, driving phenotypic diversity and genetic disease. Although highly diverse, their repetitive sequences induce DNA polymerase slippage and stalling, leading to length and sequence variation. However, current studies of DNA synthesis through STRs are restricted to a handful of selected sequences, limiting our broader un...

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Literature Corpus work: a263f106-3f1d-55db-af6b-48f6ecd97350
DOI: 10.1101/2020.06.20.162743

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