Article

A novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells

2020-08-27

Abstract excerpt

<title>Abstract</title> <p><bold>Abstract </bold>Single strand breaks (SSBs) represent the major form of DNA damage, yet no technique exists to map these lesions genome-wide with nucleotide-level precision. Herein, we present a method, termed SSiNGLe, and demonstrate its utility to explore the distribution and dynamic changes of genome-wide SSBs in response to different biological and environmental stimuli. We va...

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Literature Corpus work: 58d109d1-16f7-5d43-b79a-b39f7ab8a17a
DOI: 10.21203/rs.3.pex-920/v2

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