Article

Landscape and mutational dynamics of G-quadruplexes in the complete human genome and in haplotypes of diverse ancestry

2025-06-23

Abstract excerpt

G-quadruplexes (G4s) are alternative DNA structures with diverse biological roles, but their examination in highly repetitive parts of the human genome has been hindered by the lack of reliable sequencing technologies. Recent long-read based genome assemblies have enabled their characterization in previously inaccessible parts of the human genome. Here, we examine the topography and genomic instability of potentia...

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Literature Corpus work: bfc504f6-38a1-5c71-bcda-0f080d601ba8
DOI: 10.1101/2025.06.17.660256

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