Article

Association of a Common Genetic Variant with Parkinson’s Disease is Propagated through Microglia

2021-01-17

Abstract excerpt

Studies of the genetic basis of Parkinson’s disease (PD) have identified many disease-associated genetic variants, but the mechanisms linking variants to pathogenicity are largely unknown. PD risk is attributed to both coding mutations in the Leucine-rich repeat kinase 2 ( LRRK2 ) gene and to common non-coding variation upstream of the LRRK2 locus. Here we show that the influence of genotype at non-coding varian...

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Literature Corpus work: 45a1412b-859d-5fd8-ac3f-a7213a90f05c
DOI: 10.1101/2021.01.15.426824

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