Article
17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson's disease are associated with LRRC37A/2 expression in astrocytes.
Molecular neurodegeneration - 15 Jul 2022
Bowles Kathryn R, Pugh Derian A, Liu Yiyuan, Patel Tulsi, Renton Alan E, Bandres-Ciga Sara, Gan-Or Ziv, Heutink Peter, Siitonen Ari, Bertelsen Sarah, Cherry Jonathan D, Karch Celeste M, Frucht Steven J, Kopell Brian H, Peter Inga, Park Y J, Charney Alexander, Raj Towfique, Crary John F, Goate A M
Abstract excerpt
BACKGROUND: Parkinson's disease (PD) is genetically associated with the H1 haplotype of the MAPT 17q.21.31 locus, although the causal gene and variants underlying this association have not been identified. METHODS: To better understand the genetic contribution of this region to PD and to identify novel mechanisms conferring risk for the disease, we fine-mapped the 17q21.31 locus by constructing discrete haplotype...
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