Article

Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability

2018-10-16

Abstract excerpt

Parkinson’s disease (PD), with its characteristic loss of nigrostriatal dopaminergic neurons and deposition of α-synuclein in neurons, is often considered a neuronal disorder. However, in recent years substantial evidence has emerged to implicate glial cell types, such as astrocytes and microglia. In this study, we used stratified LD score regression and expression-weighted cell-type enrichment together with sever...

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Literature Corpus work: bbc049d5-0efa-598b-8ac3-9135fa196aad
DOI: 10.1101/442152

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