Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability

Abstract excerpt

Parkinson's disease (PD), with its characteristic loss of nigrostriatal dopaminergic neurons and deposition of α-synuclein in neurons, is often considered a neuronal disorder. However, in recent years substantial evidence has emerged to implicate glial cell types, such as astrocytes and microglia. In this study, we used stratified LD score regression and expression-weighted cell-type enrichment together with...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neuroinflammation and Neurodegeneration Mechanisms
• Share to Parkinson's Disease Mechanisms and Treatments
• Share to RNA regulation and disease