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Article

Cell-Type-Specific Causal Inference Unveils Novel Targets for Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Jun 2026

Gu Si-Chun, Sun Qiao Yang, Zhang Wei, Shen Chang-Yi, Su Hang, Xie Fang, Yuan Can-Xing, Zhou Zhi-Dong, Tan Eng King, Ye Qing

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) involves heterogeneous neurodegenerative processes across brain cell types. The cell-type-specific effects of genetic risk remain unclear. OBJECTIVE: We aimed to identify cell-type-specific causal genes for PD and to link genetic risk to molecular mechanisms and therapeutic opportunities. METHODS: We performed the first cell-stratified Mendelian randomization integrating...

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Identifiers

PMID: 41684331
DOI: 10.1002/mds.70223

Genes

ARL17A
ARL17B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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