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Article

Fine-mapping of Parkinson's disease susceptibility loci identifies putative causal variants.

Human molecular genetics - 21 Mar 2022

Schilder Brian M, Raj Towfique

Abstract excerpt

Recent genome-wide association studies have identified 78 loci associated with Parkinson's disease susceptibility but the underlying mechanisms remain largely unclear. To identify likely causal variants for disease risk, we fine-mapped these Parkinson's-associated loci using four different fine-mapping methods. We then integrated multi-assay cell type-specific epigenomic profiles to pinpoint the likely mechanism...

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Identifiers

PMID: 34617105
DOI: 10.1093/hmg/ddab294
PMCID: PMC8947317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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