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Single-cell eQTL mapping reveals convergent glial–neuronal risk architecture in Parkinson’s disease

2026-04-24

Abstract excerpt

Synucleinopathies affect ∼15 million people and are classically divided into neuronal (Parkinson’s disease (PD), dementia with Lewy bodies) and glial (multiple system atrophy) disorders. Here we challenge this dichotomy. We functionally fine-map 90 PD GWAS signals across nine cell types in cortex and substantia nigra using disease-context, population-scale single-nucleus eQTL meta-analysis (N = 1,197), bulk brain...

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Identifiers and source

Literature Corpus work
18676ae8-0518-56b7-9fcc-40a76acb33b7
DOI
10.64898/2026.04.24.720642
Open publication

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Single-cell eQTL mapping reveals convergent glial–neuronal risk architecture in Parkinson’s diseaseDOI 10.64898/2026.04.24.720642
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