Association of a common genetic variant with Parkinson’s disease is mediated by microglia

Abstract excerpt

Studies of multiple neurodegenerative disorders have identified many genetic variants that are associated with risk of disease throughout a lifetime. For example, Parkinson’s disease (PD) risk is attributed in part to both coding mutations in the leucine-rich repeat kinase 2 ( LRRK2 ) gene and to a common noncoding variation in the 5′ region of the LRRK2 locus, as identified by genome-wide association studies...

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