Article

Early Reprogramming Intermediates Enable Direct Neuronal Conversion via NGN2

2025-08-04

Abstract excerpt

The generation of engineered neurons via Neurogenin-2 (NGN2) overexpression, starting from human induced pluripotent stem cells (hiPSCs), is a powerful tool for modeling neurological diseases. However, using stabilized hiPSCs as a starting point significantly increases the time required to obtain a valuable human neuronal model in vitro. Here, we demonstrated that as little as 3 days of transient expression of rep...

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Literature Corpus work: 1049e297-6f36-5865-9c60-1d02ba2a18f7
DOI: 10.1101/2025.08.04.668497

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