Article

A Novel Transcription Factor Combination for Direct Reprogramming to a Spontaneously Contracting Human Cardiomyocyte-like State

2023-03-15

Abstract excerpt

<h4>ABSTRACT</h4> The reprogramming of somatic cells to a spontaneously contracting cardiomyocyte-like state using defined transcription factors has proven successful in mouse fibroblasts. However, this process has been less successful in human cells, thus limiting the potential clinical applicability of this technology in regenerative medicine. We hypothesized that this issue is due to a lack of cross-species co...

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Literature Corpus work: 149a055b-ac04-580e-9433-36737b158487
DOI: 10.1101/2023.03.14.532629

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