Article

Human neuron subtype programming through combinatorial patterning with scRNA-seq readouts

2023-12-13

Abstract excerpt

Human neurons programmed through transcription factor (TF) overexpression model neuronal differentiation and neurological diseases. However, programming specific neuron types remains challenging. Here, we modulate developmental signaling pathways combined with TF overexpression to explore the spectrum of neuron subtypes generated from pluripotent stem cells. We screened 480 morphogen signaling modulations coupled...

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Literature Corpus work: bb0a96bd-0c89-5962-994d-86f744f6e6fa
DOI: 10.1101/2023.12.12.571318

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