Article

Efficient generation of lower induced Motor Neurons by coupling <i>Ngn2</i> expression with developmental cues

2022-01-12

Abstract excerpt

<h4>SUMMARY</h4> Human pluripotent stem cells (hPSCs) are a powerful tool for disease modelling and drug discovery, especially when access to primary tissue is limited, such as in the brain. Current neuronal differentiation approaches use either small molecules for directed differentiation or transcription-factor-mediated programming. In this study we coupled the overexpression of the neuralising transcription fa...

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Literature Corpus work: 914aa10d-bc12-5d55-81a6-3a92ee293dbc
DOI: 10.1101/2022.01.12.476020

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