A Snapshot of Early Transcriptional Changes Accompanying the Pro-Neural Phenotype Switch by NGN2, ASCL1, SOX2, and MSI1 in Human Fibroblasts: An RNA-Seq Study.

doi:10.3390/ijms252212385

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Article

A Snapshot of Early Transcriptional Changes Accompanying the Pro-Neural Phenotype Switch by NGN2, ASCL1, SOX2, and MSI1 in Human Fibroblasts: An RNA-Seq Study.

International journal of molecular sciences - 18 Nov 2024

Samoilova Ekaterina M, Chudakova Daria A, Dashinimaev Erdem B, Snezhkina Anastasiya V, Kudryashova Olga M, Lipatova Anastasia V, Soboleva Alesya V, Vorob'yev Pavel O, Valuev-Elliston Vladimir T, Zakirova Natalia F, Ivanov Alexander V, Baklaushev Vladimir P

Abstract excerpt

Direct pro-neural reprogramming is a conversion of differentiated somatic cells to neural cells without an intermediate pluripotency stage. It is usually achieved via ectopic expression (EE) of certain transcription factors (TFs) or other reprogramming factors (RFs). Determining the transcriptional changes (TCs) caused by particular RFs in a given cell line enables an informed approach to reprogramming...

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PMID: 39596450
DOI: 10.3390/ijms252212385
PMCID: PMC11594342

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