Article

A Spatial Risk Model Reveals a 25 μm Transcriptomic Event Horizon for Plaque-Associated Myeloid Activation in Alzheimer’s Disease

2026-07-31

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Spatial transcriptomics has enabled high-resolution mapping of Alzheimer’s disease (AD) pathology; however, the precise spatial boundary at which homeostatic microglia and perivascular macrophages (PVMs) transition into a disease-associated state remains poorly defined. Existing trajectory-based approaches generally model activation as a gradual continuum and...

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Literature Corpus work: 451f8a5d-dbe5-513d-b1ed-bec4f3148c0b
DOI: 10.21203/rs.3.rs-10537597/v1

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