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Article

Spatially Resolved Microglial Expression Around Aβ Plaques in Human Alzheimer’s Disease Tissue

2025-09-03

Abstract excerpt

<h4>Summary</h4> Using microglia-enriched spatial transcriptomics on human Alzheimer’s disease tissue, we identify distinct gene expression changes across microglia located in direct contact with plaques, in periplaque regions, and in areas distant from plaques. We define a group of plaque contact–only microglial (PCOM) genes whose expression increases exclusively in microglia directly contacting plaques. These g...

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Literature Corpus work
dfda60bf-e1dc-51a6-97bc-2101b27ad908
DOI
10.1101/2025.08.29.673089
Open publication

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Spatially Resolved Microglial Expression Around Aβ Plaques in Human Alzheimer’s Disease TissueDOI 10.1101/2025.08.29.673089
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