Article

sc4D: spatio-temporal single-cell transcriptomics analysis through embedded optimal transport identifies joint glial response to Alzheimer’s disease pathology

2025-11-19

Abstract excerpt

A precise understanding of disease-associated spatio-temporal transcriptional dynamics is critical for nominating therapeutic interventions that drive desired perturbation responses. In disease contexts, pathological processes unfold across diverse cellular states, spatial environments, and timescales; however, current computational approaches have a limited ability to jointly model these complex dynamics or infer...

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Literature Corpus work: 12a363d3-9cf1-586e-9c43-6ce7d0b96cd2
DOI: 10.1101/2025.11.19.689166

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