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Fokker-Planck diffusion maps of multiple single cell microglial transcriptomes reveals radial differentiation into substates associated with Alzheimer’s pathology

2024-06-27

Abstract excerpt

The identification of microglia subtypes is important for understanding the role of innate immunity in neu-rodegenerative diseases. Current methods of unsupervised cell type identification assume a small noise-to-signal ratio of transcriptome measurements that would produce well-separated cell clusters. However, identification of subtypes is obscured by gene expression noise, diminishing the distances in transcrip...

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Literature Corpus work
a34a14e7-7386-5b90-b971-f0714215bbd1
DOI
10.1101/2024.06.21.599924
Open publication

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Fokker-Planck diffusion maps of multiple single cell microglial transcriptomes reveals radial differentiation into substates associated with Alzheimer’s pathologyDOI 10.1101/2024.06.21.599924
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