Article

Spatiotemporal characterization of glial cell activation in an Alzheimer’s disease model by spatially resolved transcriptome

2021-06-29

Abstract excerpt

<h4>ABSTRACT</h4> The pathophysiological changes that occur with the progression of Alzheimer’s disease (AD) are well known, but understanding the spatiotemporal heterogeneity of the brain is needed. Here, we investigated the spatially resolved transcriptome in a 5XFAD AD model of different ages to understand regional changes at the molecular level. We identified early alterations in the white matter (WM) of the...

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Literature Corpus work: 45dc9f13-024b-56fe-837f-4b7509758e07
DOI: 10.1101/2021.06.28.450154

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