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Article

Single-cell transcriptomic and genomic changes in the ageing human brain.

Nature - 1 Oct 2025

Jeffries Ailsa M, Yu Tianxiong, Ziegenfuss Jennifer S, Tolles Allie K, Baer Christina E, Sotelo Cesar Bautista, Kim Yerin, Weng Zhiping, Lodato Michael A

Abstract excerpt

Over time, cells in the brain and in the body accumulate damage, which contributes to the ageing process1. In the human brain, the prefrontal cortex undergoes age-related changes that can affect cognitive functioning later in life2. Here, using single-nucleus RNA sequencing (snRNA-seq), single-cell whole-genome sequencing (scWGS) and spatial transcriptomics, we identify gene-expression and genomic changes in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40903571
DOI: 10.1038/s41586-025-09435-8
PMCID: PMC12527935

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