Alzheimer's disease risk genes and mechanisms of disease pathogenesis.

doi:10.1016/j.biopsych.2014.05.006

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Article

Alzheimer's disease risk genes and mechanisms of disease pathogenesis.

Biological psychiatry - 1 Jan 2015

Karch Celeste M, Goate Alison M

Abstract excerpt

We review the genetic risk factors for late-onset Alzheimer's disease (AD) and their role in AD pathogenesis. More recent advances in understanding of the human genome-technologic advances in methods to analyze millions of polymorphisms in thousands of subjects-have revealed new genes associated with AD risk, including ABCA7, BIN1, CASS4, CD33, CD2AP, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB5-DBR1, INPP5D,...