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Deletion of smooth muscle O-GlcNAc transferase prevents development of atherosclerosis in western diet-fed hyperglycemic ApoE <sup>-/-</sup> mice in vivo

2023-03-23

Abstract excerpt

Accumulating evidence highlights protein O-GlcNAcylation as a putative pathogenic contributor of diabetic vascular complications. We previously reported that elevated protein O-GlcNAcylation correlates with increased atherosclerotic lesion formation and VSMC proliferation in response to hyperglycemia. However, the role of O-GlcNAc transferase (OGT), regulator of O-GlcNAc signaling, in evolution of diabetic atheros...

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Literature Corpus work
44b580e8-9812-5250-aa5e-fa655bebe9eb
DOI
10.1101/2023.03.20.533533
Open publication

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Deletion of smooth muscle O-GlcNAc transferase prevents development of atherosclerosis in western diet-fed hyperglycemic ApoE <sup>-/-</sup> mice in vivoDOI 10.1101/2023.03.20.533533
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