Article
Fine-tuning the cardiac O-GlcNAcylation regulatory enzymes governs the functional and structural phenotype of the diabetic heart.
Cardiovascular research - 7 Jan 2022
Prakoso Darnel, Lim Shiang Y, Erickson Jeffrey R, Wallace Rachel S, Lees Jarmon G, Tate Mitchel, Kiriazis Helen, Donner Daniel G, Henstridge Darren C, Davey Jonathan R, Qian Hongwei, Deo Minh, Parry Laura J, Davidoff Amy J, Gregorevic Paul, Chatham John C, De Blasio Miles J, Ritchie Rebecca H
Abstract excerpt
AIMS: The glucose-driven enzymatic modification of myocardial proteins by the sugar moiety, β-N-acetylglucosamine (O-GlcNAc), is increased in pre-clinical models of diabetes, implicating protein O-GlcNAc modification in diabetes-induced heart failure. Our aim was to specifically examine cardiac manipulation of the two regulatory enzymes of this process on the cardiac phenotype, in the presence and absence of...
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