Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased atherosclerosis and endothelial dysfunction in mice bearing constitutively deacetylated alleles of Foxo1 gene.

The Journal of biological chemistry - 20 Apr 2012

Qiang Li, Tsuchiya Kyoichiro, Kim-Muller Ja-Young, Lin Hua V, Welch Carrie, Accili Domenico

Abstract excerpt

Complications of atherosclerosis are the leading cause of death of patients with type 2 (insulin-resistant) diabetes. Understanding the mechanisms by which insulin resistance and hyperglycemia contribute to atherogenesis in key target tissues (liver, vessel wall, hematopoietic cells) can assist in the design of therapeutic approaches. We have shown that hyperglycemia induces FoxO1 deacetylation and that targeted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Atherosclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Marrow Transplantation

Share to Endothelial Cells

Share to Endothelium, Vascular

Share to Forkhead Box Protein O1

Share to Forkhead Transcription Factors

Share to Hyperglycemia

Source

Open in PubMed Open full text

Identifiers

PMID: 22389493
DOI: 10.1074/jbc.M111.332767
PMCID: PMC3340149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased atherosclerosis and endothelial dysfunction in mice bearing constitutively deacetylated alleles of Foxo1 gene.PMID 22389493Read ↗

Homozygosity for an allele encoding deacetylated FoxO1 protects macrophages from cholesterol-induced inflammation without increasing apoptosis.Semantic proximity Read ↗

Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice.Semantic proximity Read ↗

Insulin sensitization by hepatic FoxO deletion is insufficient to lower atherosclerosis in miceSemantic proximity Read ↗

Up-regulation of FoxO1 contributes to adverse vascular remodelling in type 1 diabetic rats.Semantic proximity Read ↗

Lectin-like oxidized low-density lipoprotein receptor-1 promotes endothelial dysfunction in LDL receptor knockout background.Semantic proximity Read ↗

FoxO1 Deacetylation Decreases Fatty Acid Oxidation in β-Cells and Sustains Insulin Secretion in Diabetes.Semantic proximity Read ↗

Deficiency of LRP1 in Mature Adipocytes Promotes Diet-Induced Inflammation and Atherosclerosis-Brief Report.Semantic proximity Read ↗

A novel non-genetic murine model of hyperglycemia and hyperlipidemia-associated aggravated atherosclerosisSemantic proximity Read ↗

PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment.Semantic proximity Read ↗

Diabetic atherosclerosis in APOE*4 mice: synergy between lipoprotein metabolism and vascular inflammation.Semantic proximity Read ↗

Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice.Semantic proximity Read ↗

FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.