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Article

A Glyoxalase-1 Knockdown Does Not Have Major Short Term Effects on Energy Expenditure and Atherosclerosis in Mice.

Journal of diabetes research - 1 Jan 2016

Wortmann Markus, Hakimi Maani, Fleming Thomas, Peters Andreas S, Sijmonsma Tjeerd P, Herzig Stephan, Nawroth Peter P, Böckler Dittmar, Dihlmann Susanne

Abstract excerpt

Objective. Glyoxalase-1 is an enzyme detoxifying methylglyoxal (MG). MG is a potent precursor of advanced glycation endproducts which are regarded to be a key player in micro- and macrovascular damage. Yet, the role of Glo1 in atherosclerosis remains unclear. In this study, the effect of Glo1 on mouse metabolism and atherosclerosis is evaluated. Methods. Glo1 knockdown mice were fed a high fat or a standard diet...

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Source

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Identifiers

PMID: 26788517
DOI: 10.1155/2016/2981639
PMCID: PMC4693023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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