Article

MYPT1 O-GlcNAc modification controls the sensitivity of fibroblasts to sphingosine-1-phosphate mediated cellular contraction

2019-10-08

Abstract excerpt

<h4>ABSTRACT</h4> Many intracellular proteins can be modified by N-acetylglucosamine, a posttranslational modification known as O-GlcNAc. Because this modification is found on serine and threonine side-chains, O-GlcNAc has the potential to dynamically regulate cellular signaling pathways through interplay with phosphorylation. Here, we discover and characterize one such example. First, we find that O-GlcNAc level...

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Literature Corpus work: 900a588d-bb24-5dc4-9f95-8a67b00f6421
DOI: 10.1101/796672

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