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Article

Methyltransferase-like 3-catalysed N6-methyladenosine methylation facilitates the contribution of vascular smooth muscle cells to atherosclerosis.

Cardiovascular research - 6 May 2025

Dong Zhigang, Jin Yourong, Shen Yicong, Huang Jiaqi, Tan Jiaai, Feng Qianqian, Gong Ze, Zhu Shirong, Chen Huiyue, Yu Fang, Li Wei, Jia Yiting, Kong Wei, Fu Yi

Abstract excerpt

AIMS: Vascular smooth muscle cells (VSMCs) are involved in the aetiology of atherosclerosis, but whether methyltransferase-like 3 (METTL3)-catalysed N6-methyladenosine (m6A) modulates the contribution of VSMCs to atherosclerosis remains elusive. METHODS AND RESULTS: We generated tamoxifen-inducible VSMC-specific METTL3 knockout mice with VSMC lineage tracing and found that VSMC-specific METTL3 deficiency...

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Share to Adenosine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Methylation

Share to Methyltransferases

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Plaque, Atherosclerotic

Source

Identifiers

PMID: 39977233
DOI: 10.1093/cvr/cvaf029

Genes

METTL3
MRTFA
YTHDF3
F3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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