Article

Excessive <i>O</i> - GlcNAcylation causes heart failure and sudden death

2020-02-12

Abstract excerpt

<h4>Background</h4> Heart failure is a leading cause of death worldwide and is associated with the rising prevalence of obesity, hypertension and diabetes. O- GlcNAcylation, a post-translational modification of intracellular proteins, serves as a potent transducer of cellular stress. Failing myocardium is marked by increased O -GlcNAcylation, but it is unknown if excessive O- GlcNAcylation contributes to cardi...

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Literature Corpus work: 0d210a61-22ad-594a-bbf0-465a56a1bd21
DOI: 10.1101/2020.02.11.943910

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