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Article

Up-regulation of FoxO1 contributes to adverse vascular remodelling in type 1 diabetic rats.

Journal of cellular and molecular medicine - 1 Dec 2020

Liu Jingjin, Xie Xiang, Yan Dan, Wang Yongshun, Yuan Hongbin, Cai Yin, Luo Jierong, Xu Aimin, Huang Yu, Cheung Chi Wai, Irwin Michael G, Xia Zhengyuan

Abstract excerpt

Vascular complications from diabetes often result in poor outcomes for patients, even after optimized interventions. Forkhead box protein O1 (FoxO1) is a key regulator of cellular metabolism and plays an important role in vessel formation and maturation. Alterations of FoxO1 occur in the cardiovascular system in diabetes, yet the role of FoxO1 in diabetic vascular complications is poorly understood. In...

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Identifiers

PMID: 33108705
DOI: 10.1111/jcmm.15935
PMCID: PMC7754018

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