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Differentiation of human T follicular helper cells <i>in vitro</i> requires co-operation between STAT3 and SMAD signaling cytokines that is restrained by IL-2

2025-01-15

Abstract excerpt

T follicular helper cells (TFH) are a CD4 T cell subset required for effective humoral immunity; promoting antibody responses to vaccines and natural infections. The mechanisms by which human TFH differentiate are not fully understood, and given the anatomical localization to the secondary lymphoid tissues, and asynchronous nature of in vivo TFH populations, studying TFH differentiation in vitro represents an at...

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Literature Corpus work
449f2d91-0cb5-5025-9fb8-9acbb6fa60a7
DOI
10.1101/2025.01.12.632620
Open publication

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Differentiation of human T follicular helper cells <i>in vitro</i> requires co-operation between STAT3 and SMAD signaling cytokines that is restrained by IL-2DOI 10.1101/2025.01.12.632620
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