Article
Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies.
The Journal of allergy and clinical immunology - 1 Oct 2015
Ma Cindy S, Wong Natalie, Rao Geetha, Avery Danielle T, Torpy James, Hambridge Thomas, Bustamante Jacinta, Okada Satoshi, Stoddard Jennifer L, Deenick Elissa K, Pelham Simon J, Payne Kathryn, Boisson-Dupuis Stéphanie, Puel Anne, Kobayashi Masao, Arkwright Peter D, Kilic Sara Sebnem, El Baghdadi Jamila, Nonoyama Shigeaki, Minegishi Yoshiyuki, Mahdaviani Seyed Alireza, Mansouri Davood, Bousfiha Aziz, Blincoe Annaliesse K, French Martyn A, Hsu Peter, Campbell Dianne E, Stormon Michael O, Wong Melanie, Adelstein Stephen, Smart Joanne M, Fulcher David A, Cook Matthew C, Phan Tri Giang, Stepensky Polina, Boztug Kaan, Kansu Aydan, İkincioğullari Aydan, Baumann Ulrich, Beier Rita, Roscioli Tony, Ziegler John B, Gray Paul, Picard Capucine, Grimbacher Bodo, Warnatz Klaus, Holland Steven M, Casanova Jean-Laurent, Uzel Gulbu, Tangye Stuart G
Abstract excerpt
BACKGROUND: Follicular helper T (TFH) cells underpin T cell-dependent humoral immunity and the success of most vaccines. TFH cells also contribute to human immune disorders, such as autoimmunity, immunodeficiency, and malignancy. Understanding the molecular requirements for the generation and function of TFH cells will provide strategies for targeting these cells to modulate their behavior in the setting of these...
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