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Article

What determines Th2 differentiation, <i>in vitro</i> and <i>in vivo</i>?

16 Feb 2010

Abstract excerpt

We have known since 1991 how to induce naive CD4 T cells to differentiate in vitro into Th2 cells and, over the ensuing years, a comprehensive picture of the molecules involved in this important process has emerged. GATA3 and STAT5 are both essential for in vitro differentiation, stimulating naive cells through a process involving induction, which is T-cell receptor (TCR) dependent but interleukin (IL)-4...

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PMID: 20157328
DOI: 10.1038/icb.2010.2

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