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Article

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

Blood - 26 Apr 2012

Ma Cindy S, Avery Danielle T, Chan Anna, Batten Marcel, Bustamante Jacinta, Boisson-Dupuis Stephanie, Arkwright Peter D, Kreins Alexandra Y, Averbuch Diana, Engelhard Dan, Magdorf Klaus, Kilic Sara S, Minegishi Yoshiyuki, Nonoyama Shigeaki, French Martyn A, Choo Sharon, Smart Joanne M, Peake Jane, Wong Melanie, Gray Paul, Cook Matthew C, Fulcher David A, Casanova Jean-Laurent, Deenick Elissa K, Tangye Stuart G

Abstract excerpt

T follicular helper (Tfh) cells are critical for providing the necessary signals to induce differentiation of B cells into memory and Ab-secreting cells. Accordingly, it is important to identify the molecular requirements for Tfh cell development and function. We previously found that IL-12 mediates the differentiation of human CD4(+) T cells to the Tfh lineage, because IL-12 induces naive human CD4(+) T cells to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22403255
DOI: 10.1182/blood-2011-11-392985
PMCID: PMC3355712

Genes

STAT3
TYK2
CXCR5
STAT1
BCL6
ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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Functional STAT3 deficiency compromises the generation of human T follicular helper cells.PMID 22403255Read ↗

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Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.Semantic proximity Read ↗

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