Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles.

Scientific reports - 23 Feb 2018

Alshekaili Jalila, Chand Rochna, Lee Cindy Eunhee, Corley Susan, Kwong Kristy, Papa Ilenia, Fulcher David A, Randall Katrina L, Leiding Jennifer W, Ma Cindy S, Wilkins Marc R, Uzel Gulbu, Goodnow Chris C, Vinuesa Carola G, Tangye Stuart G, Cook Matthew C

Abstract excerpt

A subset of human follicular helper T cells (TFH) cells expresses CD57 for which no distinct function has been identified. We show that CD57+ TFH cells are universally PD-1hi, but compared to their CD57- PD-1hi counterparts, express little IL-21 or IL-10 among others. Instead, CD57 expression on TFH cells marks cytotoxicity transcriptional signatures that translate into only a weak cytotoxic phenotype. Similarly,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD57 Antigens
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-21

Share to Palatine Tonsil

Share to Primary Cell Culture

Share to Programmed Cell Death 1 Receptor

Share to STAT3 Transcription Factor

Share to T-Lymphocytes, Helper-Inducer

Source

Open in PubMed Open full text

Identifiers

PMID: 29476109
DOI: 10.1038/s41598-018-21389-8
PMCID: PMC5824848

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles.PMID 29476109Read ↗

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies.Semantic proximity Read ↗

CTLA4 protects against maladaptive cytotoxicity during differentiation of effector and follicular CD4+ T cellsSemantic proximity Read ↗

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.Semantic proximity Read ↗

Differentiation of human T follicular helper cells <i>in vitro</i> requires co-operation between STAT3 and SMAD signaling cytokines that is restrained by IL-2Semantic proximity Read ↗

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.Semantic proximity Read ↗

IL-27 maintains cytotoxic Ly6C <sup>+</sup> γδ T cells that arise from immature precursorsSemantic proximity Read ↗

Human follicular CD4 T cell function is defined by specific molecular, positional and TCR dynamic signaturesSemantic proximity Read ↗

The Era of Cytotoxic CD4 T CellsSemantic proximity Read ↗

Acquisition of optimal TFH cell function is defined by specific molecular, positional, and TCR dynamic signatures.Semantic proximity Read ↗

The transcription factors Runx3 and ThPOK cross-regulate acquisition of cytotoxic function by human Th1 lymphocytesSemantic proximity Read ↗

CD28 and CD57 define four populations with distinct phenotypic properties within human CD8+ T cells.Semantic proximity Read ↗

IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.