Acquisition of optimal TFH cell function is defined by specific molecular, positional, and TCR dynamic signatures.

doi:10.1073/pnas.2016855118

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Article

Acquisition of optimal TFH cell function is defined by specific molecular, positional, and TCR dynamic signatures.

Proceedings of the National Academy of Sciences of the United States of America - 4 May 2021

Padhan Kartika, Moysi Eirini, Noto Alessandra, Chassiakos Alexander, Ghneim Khader, Perra Maria Maddalena, Shah Sanjana, Papaioannou Vasilis, Fabozzi Giulia, Ambrozak David R, Poultsidi Antigoni, Ioannou Maria, Fenwick Craig, Darko Samuel, Douek Daniel C, Sekaly Rafick-Pierre, Pantaleo Giuseppe, Koup Richard A, Petrovas Constantinos

Abstract excerpt

The development of follicular helper CD4 T (TFH) cells is a dynamic process resulting in a heterogenous pool of TFH subsets. However, the cellular and molecular determinants of this heterogeneity and the possible mechanistic links between them is not clear. We found that human TFH differentiation is associated with significant changes in phenotypic, chemokine, functional, metabolic and transcriptional profile....

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Identifiers

PMID: 33903232
DOI: 10.1073/pnas.2016855118
PMCID: PMC8106351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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