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Termination of CD40L co‐stimulation promotes human B cell differentiation into antibody‐secreting cells

8 Sept 2022

Abstract excerpt

Abstract Human naïve B cells are notoriously difficult to differentiate into antibody‐secreting cells (ASCs) in vitro while maintaining sufficient cell numbers to evaluate the differentiation process. B cells require T follicular helper (T FH ) cell‐derived signals like CD40L and IL‐21 during germinal center (GC) responses to undergo differentiation into ASCs. Cognate interactions between B and T FH cells are...

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PMID: 36073009
DOI: 10.1002/eji.202249972

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