Article

Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival

2018-10-16

Abstract excerpt

Genomic instability pathways in colorectal cancer (CRC) have been extensively studied, but the role of retrotransposition in colorectal carcinogenesis remains poorly understood. Although retrotransposons are usually repressed, they become active in several human cancers, in particular those of the gastrointestinal tract. Here we characterize retrotransposon insertions in 202 colorectal tumor whole genomes and inve...

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Literature Corpus work: 44839fdc-6f36-5b89-9820-44812d9f6ca6
DOI: 10.1101/443580

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