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Article

The interaction between cytosine methylation and processes of DNA replication and repair shape the mutational landscape of cancer genomes.

Nucleic acids research - 27 Jul 2017

Poulos Rebecca C, Olivier Jake, Wong Jason W H

Abstract excerpt

Methylated cytosines (5mCs) are frequently mutated in the genome. However, no studies have yet comprehensively analysed mutation-methylation associations across cancer types. Here we analyse 916 cancer genomes, together with tissue type-specific methylation and replication timing data. We describe a strong mutation-methylation association across colorectal cancer subtypes, most interestingly in samples with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28531315
DOI: 10.1093/nar/gkx463
PMCID: PMC5737810

Genes

POLE
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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