Article
Detection of subclonal L1 transductions in colorectal cancer by long-distance inverse-PCR and Nanopore sequencing.
Scientific reports - 6 Nov 2017
Pradhan Barun, Cajuso Tatiana, Katainen Riku, Sulo Päivi, Tanskanen Tomas, Kilpivaara Outi, Pitkänen Esa, Aaltonen Lauri A, Kauppi Liisa, Palin Kimmo
Abstract excerpt
Long interspersed nuclear elements-1 (L1s) are a large family of retrotransposons. Retrotransposons are repetitive sequences that are capable of autonomous mobility via a copy-and-paste mechanism. In most copy events, only the L1 sequence is inserted, however, they can also mobilize the flanking non-repetitive region by a process known as 3' transduction. L1 insertions can contribute to genome plasticity and...
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