Article

Profiling diverse sequence tandem repeats in colorectal cancer reveals co-occurrence of microsatellite and chromosomal instability involving Chromosome 8

2020-12-24

Abstract excerpt

<h4>ABSTRACT</h4> Colorectal carcinomas (CRCs) which have lost DNA mismatch repair display hypermutability evident in a molecular phenotype called microsatellite instability (MSI) . These mismatch repair deficient tumors are thought to lack widespread genomic instability features, such as copy number changes and rearrangements. To identify MSI for clinical diagnosis, current molecular testing looks for changes...

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Literature Corpus work: c08d4777-616e-5509-9123-ef87ffb9844f
DOI: 10.1101/2020.12.23.422767

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