Article

The mutational landscape of single neurons and oligodendrocytes reveals evidence of inflammation-associated DNA damage in multiple sclerosis

2022-04-30

Abstract excerpt

Neuroinflammation has been linked to DNA damage in multiple sclerosis (MS), but its impact on neural cell genomes at nucleotide resolution is unknown. To address this question, we performed single nucleus whole genome sequencing to determine the landscape of somatic mutation in 172 neurons and oligodendrocytes (OLs) extracted from post-mortem brain tissue from 5 MS cases and three controls. We identified two cases...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8bf4e33b-8004-5b42-aa77-093fdb50c4e5
DOI: 10.1101/2022.04.30.490132

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The mutational landscape of single neurons and oligodendrocytes reveals evidence of inflammation-associated DNA damage in multiple sclerosisDOI 10.1101/2022.04.30.490132Read

Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes.Semantic proximity Read

Somatic variation in multiple sclerosis: from blood to brain.Semantic proximity Read

Contrasting patterns of somatic mutations in neurons and glia reveal differential predisposition to disease in the aging human brainSemantic proximity Read

Aging and neurodegeneration are associated with increased mutations in single human neuronsSemantic proximity Read

Single nuclei RNAseq stratifies multiple sclerosis patients into distinct white matter glial responsesSemantic proximity Read

DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patientsSemantic proximity Read

Genetic Alterations in Patients with Two Clinical Phenotypes of Multiple Sclerosis.Semantic proximity Read

The role of mitochondrial DNA variants and dysfunction in the pathogenesis and progression of multiple sclerosis.Semantic proximity Read

Mitochondrial DNA Double-Strand Breaks in Oligodendrocytes Cause Demyelination, Axonal Injury, and CNS InflammationSemantic proximity Read

Human disease-specific cell signatures in non-lesional tissue in Multiple Sclerosis detected by single-cell and spatial transcriptomicsSemantic proximity Read

The threat of programmed DNA damage to neuronal genome integrity and plasticity.Semantic proximity Read

DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patientsSemantic proximity Read